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Research Associate
Summary
Title:Research Associate
ID:1041
Description

VenatoRx Pharmaceuticals, Inc., a private, clinical-stage pharmaceutical company located in Malvern, PA has built a world-class, in-house R&D organization with over 65 employees. We are passionately focused on the discovery and development of novel anti-infectives to treat multi-drug resistant bacterial infections and hard-to-treat viral infections. All VenatoRx investigational molecules have been discovered internally and VenatoRx’s scientists have filed over 100 patents spanning multiple research programs.

The Company’s most advanced development-stage product is VNRX-5133, an injectable beta-lactamase inhibitor (BLI) that features selective and potent in vitro activity against both serine- and metallo-beta-lactamases. VenatoRx is currently developing VNRX-5133 in a fixed combination with the fourth generation cephalosporin, cefepime. VenatoRx initiated enrollment in its Phase 3 trial of cefepime/VNRX-5133 in patients with complicated urinary tract infections (cUTIs) in August 2019 and top-line results are expected by the end of 2020.

VenatoRx’s second development-stage product in clinical development is VNRX-7145, an orally bioavailable BLI that in a fixed combination with the third generation orally bioavailable cephalosporin, ceftibuten, has the potential to rescue activity of the partner antibiotic against ESBLs and key carbapenem-resistant Enterobacteriaceae, including those expressing KPC and OXA carbapenemases. Additionally, VenatoRx has a broad pipeline of pre-clinical programs including a novel class of Penicillin-Binding Protein (PBP) inhibitors that are impervious to beta-lactamase-driven resistance, and novel antiviral agents targeting Hepatitis B Virus.

We are seeking a highly motivated Research Associate to help progress breakthrough science from discovery into the clinic. The Research Associate is a laboratory intensive position within the Biology group that will be required to support early-stage drug discovery efforts as well as ongoing clinical programs. This role will be involved in all aspects of the drug discovery process.

Responsibilities include:

  • Work closely with a team of scientists within Discovery Biology to support early-stage discovery effort, pre-clinical development, and ongoing clinical programs.
  • Perform a multitude of microbiological assays including MIC testing, frequency of resistance, and time-kill experiments; biochemical assays including protein purification, enzyme IC50s, and molecular biology; cell culture and cytotoxicity testing.
  • Responsible for maintaining detailed records of experimental results.
  • Perform other duties as required

Successful candidates will be able to demonstrate:

  • Bachelor of science in biological sciences or related field
  • 0-2 years’ relevant laboratory experience in pharmaceutical or biotechnology, and/or through relevant Co-op internships
  • Able to work in a fast-paced, entrepreneurial start-up environment
  • Proven ability to work independently in a hands-on laboratory setting
  • Self-motivated to learn and develop new methods
  • Excellent organizational, communication (written and oral), and collaborations skills
  • Maintain accurate records, follow instructions, and comply with company policies and procedures
  • Able to exercise sound judgment within defined procedures and practices to determine appropriate action
  • Familiarity with Microsoft Office suite preferred

 

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